Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers
Joint Authors
Yousem, David
Schwartz, Brian S.
James, Bryan D.
Caffo, Brian
Stewart, Walter F.
Davatzikos, Christos
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
This study examined associations between polymorphisms in three genes, apolipoprotein E (APOE), angiotensin converting enzyme (ACE), and vitamin D receptor (VDR), and longitudinal change in brain volumes and white matter lesions (WML) as well as effect modification by cardiovascular factors and tibia lead concentrations.
Two MRIs, an average of 5 years apart, were obtained for 317 former organolead workers and 45 population-based controls.
Both regions-of-interest and voxel-wise analyses were conducted.
APOE ε3/ε4 and ε4/ε4 genotypes were associated with less decline in white matter volumes.
There was some evidence of interaction between genetic polymorphisms and cardiovascular risk factors (ACE and high-density lipoprotein; VDR and diabetes) on brain volume decline.
The VDR FokI ff genotype was associated with an increase in WML (no association for APOE or ACE).
This study expands our understanding of how genetic precursors of dementia and cardiovascular diseases are related to changes in brain structure.
American Psychological Association (APA)
James, Bryan D.& Caffo, Brian& Stewart, Walter F.& Yousem, David& Davatzikos, Christos& Schwartz, Brian S.. 2011. Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465972
Modern Language Association (MLA)
James, Bryan D.…[et al.]. Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers. Journal of Aging Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-465972
American Medical Association (AMA)
James, Bryan D.& Caffo, Brian& Stewart, Walter F.& Yousem, David& Davatzikos, Christos& Schwartz, Brian S.. Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-465972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465972