The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
In recent years, peroxisome proliferator-activated receptor gamma (PPARγ) has been reported to be a target for the treatment of type II diabetes.
Furthermore, it has received attention for its therapeutic potential in many other human diseases, including atherosclerosis, obesity, and cancers.
Recent studies have provided evidence that the endogenously produced PPARγ antagonist, 2,3-cyclic phosphatidic acid (cPA), which is similar in structure to lysophosphatidic acid (LPA), inhibits cancer cell invasion and metastasis in vitro and in vivo.
We recently observed that cPA negatively regulates PPARγ function by stabilizing the binding of the corepressor protein, silencing mediator of retinoic acid and thyroid hormone receptor.
We also showed that cPA prevents neointima formation, adipocyte differentiation, lipid accumulation, and upregulation of PPARγ target gene transcription.
We then analyzed the molecular mechanism of cPA's action on PPARγ.
In this paper, we summarize the current knowledge on the mechanism of PPARγ-mediated transcriptional activity and transcriptional repression in response to novel lipid-derived ligands, such as cPA.
American Psychological Association (APA)
Tsukahara, Tamotsu. 2012. The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists. PPAR Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-465978
Modern Language Association (MLA)
Tsukahara, Tamotsu. The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists. PPAR Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-465978
American Medical Association (AMA)
Tsukahara, Tamotsu. The Role of PPARγ in the Transcriptional Control by Agonists and Antagonists. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-465978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465978