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Acute, Multiple-Dose Dermal and Genetic Toxicity of Nu-3 : A Novel Antimicrobial Agent
Joint Authors
Zhang, Guozhong
Hu, Yanxin
Sun, Lun-Quan
Cao, Shanping
Sun, Juan
Wang, Ming
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nu-3 [butyl-phosphate-5′-thymidine-3′-phosphate-butyl] is a modified nucleotide that has been shown to have antimicrobial activity against a range of bacteria including Pseudomonas aeruginosa.
However, data on the toxicological profile of Nu-3 are still lacking.
In the present study, the toxicity of Nu-3 was evaluated by the following studies: acute oral toxicity, dermal and mucous membrane irritation, multiple-dose toxicity and genotoxicity in vivo and vitro.
The acute oral toxicity test in mice showed that Nu-3 had an LD50 of 2001mg/kg body weight.
The irritation tests on rats revealed that Nu-3 was not irritant, with an irritation scoring of 0.
The multiple-dose toxicity study in rats showed that Nu-3 did not cause significant changes in histology, selected serum chemistry, and hematological parameters compared to the controls.
Rats administrated with multiple-doses of Nu-3 showed no visible toxic symptoms.
Both in vitro and in vivo, Nu-3 exhibited no notable genetic toxicity.
Overall, the data suggest that Nu-3 is hypotoxic or nontoxic antimicrobial compound that warrants being further developed for treating Pseudomonas aeruginosa infection.
American Psychological Association (APA)
Sun, Juan& Hu, Yanxin& Cao, Shanping& Zhang, Guozhong& Sun, Lun-Quan& Wang, Ming. 2010. Acute, Multiple-Dose Dermal and Genetic Toxicity of Nu-3 : A Novel Antimicrobial Agent. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-465996
Modern Language Association (MLA)
Sun, Juan…[et al.]. Acute, Multiple-Dose Dermal and Genetic Toxicity of Nu-3 : A Novel Antimicrobial Agent. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-465996
American Medical Association (AMA)
Sun, Juan& Hu, Yanxin& Cao, Shanping& Zhang, Guozhong& Sun, Lun-Quan& Wang, Ming. Acute, Multiple-Dose Dermal and Genetic Toxicity of Nu-3 : A Novel Antimicrobial Agent. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-465996
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465996