![](/images/graphics-bg.png)
Does Cisapride, as a 5HT4 Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat?
Joint Authors
Mahzouni, Parvin
Motavallian, Azadeh
Babavalian, Mohammad Reza
Minaiyan, Mohsen
Andalib, Sasan
Abed, Alireza
Rabbani, Mohammad
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
There is a pressing need for research that will lead to the reveal of targets designed to analyse the possible pathways for the treatment of IBD.
Because of the probable involvement of serotonin in inflammatory conditions of intestine and the important role of 5HT4 receptors in GI function, the investigation of the role of 5HT4 receptors in the pathogenesis of IBD will be interesting.
The aim of this study was to investigate the effects of cisapride, a 5HT4 receptor agonist, in trinitrobenzenesulfonic-acid-(TNBS) induced rat colitis.
Two hours subsequent to induction of colitis using TNBS in rats, cisapride (2 mg/kg, intraperitoneally (i.p); 4 mg/kg, orally (p.o)) and dexamethasone (1 mg/kg, i.p; 2 mg/kg, p.o) were administrated for 6 days.
Animals were thereafter euthanized; macroscopic, histological, and biochemical assessments and ELISA test were carried out on distal colon samples.
Our data showed that dexamethasone treatment (i.p, p.o) significantly decreased macroscopic and microscopic damage and also biochemical markers, but there were no significant differences in aforementioned parameters between cisapride (i.p or p.o) and TNBS-treated rats.
It can be deduced that because the severity of colitis produced by TNBS is massive (through various pathways), cisapride could not bring about more colitis damages through 5HT4 receptors.
Based on the present study further researches are required for investigating the exact roles of 5HT4 receptors in the pathogenesis of ulcerative colitis.
American Psychological Association (APA)
Motavallian, Azadeh& Minaiyan, Mohsen& Rabbani, Mohammad& Mahzouni, Parvin& Andalib, Sasan& Abed, Alireza…[et al.]. 2012. Does Cisapride, as a 5HT4 Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat?. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-465999
Modern Language Association (MLA)
Motavallian, Azadeh…[et al.]. Does Cisapride, as a 5HT4 Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat?. Gastroenterology Research and Practice No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-465999
American Medical Association (AMA)
Motavallian, Azadeh& Minaiyan, Mohsen& Rabbani, Mohammad& Mahzouni, Parvin& Andalib, Sasan& Abed, Alireza…[et al.]. Does Cisapride, as a 5HT4 Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat?. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-465999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-465999