Gastric Ulceration in Diabetes Mellitus : Protective Role of Vitamin C

Joint Authors

Nwokocha, Chukwuemeka R.
Obembe, Agona O.
Osim, Eme E.
Owu, Daniel U.
Edoho, Ime E.

Source

ISRN Gastroenterology

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-06-16

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases

Abstract EN

The effect of vitamin C administration on gastric acid secretion and ulcer in diabetic rats was studied.

Vitamin C (200 mg/kg b.w.) was administered to both streptozotocin-induced diabetic and control groups orally for 28 days.

Gastric acid secretion was measured and ulcer was induced using ethanol.

Histological changes were observed in the stomach.

Basal and stimulated acid secretion in diabetic control rat was significantly (P<0.01) decreased when compared to vitamin C-treated diabetic group and control.

Administration of vitamin C significantly (P<0.05) increased the histamine-stimulated gastric acid secretion in diabetics than control while reduction in gastric secretion by ranitidine was similar compared with control.

Vitamin C treatment significantly (P<0.05) reduced ulcer index in diabetic group and increased mucus weight when compared with diabetic group which was also confirmed with photomicrographs.

The mean body weight of diabetic rats treated with vitamin C was comparable to the control.

The blood glucose level was significantly (P<0.01) reduced in diabetic group given vitamin C (8.9±1.8 mMol/L) compared to the diabetic control (32.2±2.1 g).

It is concluded that vitamin C is beneficial in improving gastric acid secretion and protects against ulceration in streptozotocin-induced diabetes mellitus in rats due to its antioxidant potential.

American Psychological Association (APA)

Owu, Daniel U.& Obembe, Agona O.& Nwokocha, Chukwuemeka R.& Edoho, Ime E.& Osim, Eme E.. 2012. Gastric Ulceration in Diabetes Mellitus : Protective Role of Vitamin C. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-466019

Modern Language Association (MLA)

Owu, Daniel U.…[et al.]. Gastric Ulceration in Diabetes Mellitus : Protective Role of Vitamin C. ISRN Gastroenterology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-466019

American Medical Association (AMA)

Owu, Daniel U.& Obembe, Agona O.& Nwokocha, Chukwuemeka R.& Edoho, Ime E.& Osim, Eme E.. Gastric Ulceration in Diabetes Mellitus : Protective Role of Vitamin C. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-466019

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-466019