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Disseminated BCG : Complications of Intravesical Bladder Cancer Treatment
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-12
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Intravesical bacillus Calmette-Guerin (BCG) has been established as an effective treatment of superficial bladder cancer (Parker and Kommu, 2013).
However, major side effects, including pneumonitis, sepsis, and even death, may occur in <5% of patients (Gonzalez et al., 2003).
Here we present a case of severe disseminated Mycobacterium bovis following intravesical BCG administration.
Our patient is a 76-year-old gentleman with newly diagnosed superficial transitional cell carcinoma of the bladder who recently received his first intravesical BCG treatment.
He initially presented with hemoptysis and was found to have extensive patchy infiltrates bilaterally.
He was treated for pneumonia with antibiotics and then with steroids for hypersensitivity pneumonitis but continued to deteriorate.
Due to the temporal proximity of his exposure to BCG, we administered treatment for presumed disseminated BCG infection with rifampin, isoniazid, and ethambutol.
Within a 48-hour period, the patient improved dramatically.
The reported cases of infection from intravesical BCG illustrate an insidious onset with initial symptoms of low-grade fevers and cystitis but may progress to pneumonitis.
If the symptoms persist for more than 7 days or if there is clinical deterioration, RIPE therapy (with rifampin, isoniazid, pyridoxine, and ethambutol) and a fluoroquinolone should be administered for a 6–9-month course along with steroids for 4–6 weeks (Naudžiunas et al., 2012).
American Psychological Association (APA)
To, Uyen& Kim, Joyce& Chia, David. 2014. Disseminated BCG : Complications of Intravesical Bladder Cancer Treatment. Case Reports in Medicine،Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-466024
Modern Language Association (MLA)
To, Uyen…[et al.]. Disseminated BCG : Complications of Intravesical Bladder Cancer Treatment. Case Reports in Medicine No. 2014 (2014), pp.1-3.
https://search.emarefa.net/detail/BIM-466024
American Medical Association (AMA)
To, Uyen& Kim, Joyce& Chia, David. Disseminated BCG : Complications of Intravesical Bladder Cancer Treatment. Case Reports in Medicine. 2014. Vol. 2014, no. 2014, pp.1-3.
https://search.emarefa.net/detail/BIM-466024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466024