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The Vascular Microenvironment and Systemic Sclerosis
Joint Authors
Cawthon, Richard
Scholand, Mary Beth
Markewitz, Boaz
Patel, Amit
Frech, Tracy M.
Sawitzke, Allen D.
Hatton, Nathan
Source
International Journal of Rheumatology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The role of the vascular microenvironment in the pathogenesis Systemic Sclerosis (SSc) is appreciated clinically as Raynaud's syndrome with capillary nail bed change.
This manifestation of vasculopathy is used diagnostically in both limited and diffuse cutaneous subsets of SSc, and is thought to precede fibrosis.
The degree of subsequent fibrosis may also be determined by the vascular microenvironment.
This paper describes why the vascular microenvironment might determine the degree of end-organ damage that occurs in SSc, with a focus on vascular cell senescence, endothelial progenitor cells (EPC) including multipotential mesenchymal stem cells (MSC), pericytes, and angiogenic monocytes.
An explanation of the role of EPC, pericytes, and angiogenic monocytes is important to an understanding of SSc pathogenesis.
An evolving understanding of the vascular microenvironment in SSc may allow directed treatment.
American Psychological Association (APA)
Frech, Tracy M.& Hatton, Nathan& Markewitz, Boaz& Scholand, Mary Beth& Cawthon, Richard& Patel, Amit…[et al.]. 2010. The Vascular Microenvironment and Systemic Sclerosis. International Journal of Rheumatology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-466026
Modern Language Association (MLA)
Frech, Tracy M.…[et al.]. The Vascular Microenvironment and Systemic Sclerosis. International Journal of Rheumatology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-466026
American Medical Association (AMA)
Frech, Tracy M.& Hatton, Nathan& Markewitz, Boaz& Scholand, Mary Beth& Cawthon, Richard& Patel, Amit…[et al.]. The Vascular Microenvironment and Systemic Sclerosis. International Journal of Rheumatology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-466026
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466026