Impact of Duodopa on Quality of Life in Advanced Parkinson's Disease : A UK Case Series
Joint Authors
Limousin, P.
Webster, G. J. M.
Lees, A. J.
Foltynie, Thomas
James, C.
Magee, C.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-13
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Treatment options in advanced Parkinson’s disease (PD) include subcutaneous apomorphine, pallidal or subthalamic nucleus Deep Brain Stimulation (DBS), or levodopa/carbidopa intestinal gel (LCIG/Duodopa).
In this study, we describe the outcome of 12 PD patients with PD related complications started on LCIG, with respect to their quality of life measured by a disease specific validated scale—the PDQ39, together with diaries recording time spent “On,” “Off,” “Dyskinetic,” or “Asleep.” At the time of latest follow up, improvements were observed in both the PDQ39 Summary index as well as diary reports of PD symptom control following introduction of LCIG, supporting its use in well selected patients.
The use of a trial period of LCIG via naso-jejunal administration allows objective evaluation of improvement in PD symptom control in advance of the placement of the more invasive percutaneous jejunostomy procedure.
The decision to embark on LCIG, apomorphine or DBS should be supported by input from centres with experience of all 3 approaches.
Since LCIG is an expensive option, development of the most appropriate future commissioning of this therapy in the absence of Class 1 evidence requires careful scrutiny of the outcomes of its use in a broad range of published series.
American Psychological Association (APA)
Foltynie, Thomas& Magee, C.& James, C.& Webster, G. J. M.& Lees, A. J.& Limousin, P.. 2013. Impact of Duodopa on Quality of Life in Advanced Parkinson's Disease : A UK Case Series. Parkinson’s Disease،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466029
Modern Language Association (MLA)
Foltynie, Thomas…[et al.]. Impact of Duodopa on Quality of Life in Advanced Parkinson's Disease : A UK Case Series. Parkinson’s Disease No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-466029
American Medical Association (AMA)
Foltynie, Thomas& Magee, C.& James, C.& Webster, G. J. M.& Lees, A. J.& Limousin, P.. Impact of Duodopa on Quality of Life in Advanced Parkinson's Disease : A UK Case Series. Parkinson’s Disease. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466029