Reducing Haemorrhagic Transformation after Thrombolysis for Stroke : A Strategy Utilising Minocycline
Joint Authors
Thompson, Andrew
Major, Taryn
Kohler, Edith
Hankey, Graeme J.
Kelly, Andrew
Bynevelt, Michael
Alvaro, Anthony
Kho, Lay Kun
Prentice, David
Bates, Timothy R.
Blacker, David J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Haemorrhagic transformation (HT) of recently ischaemic brain is a feared complication of thrombolytic therapy that may be caused or compounded by ischaemia-induced activation of matrix metalloproteinases (MMPs).
The tetracycline antibiotic minocycline inhibits matrix MMPs and reduces macroscopic HT in rodents with stroke treated with tissue plasminogen activator (tPA).
The West Australian Intravenous Minocycline and TPA Stroke Study (WAIMATSS) aims to determine the safety and efficacy of adding minocycline to tPA in acute ischaemic stroke.
The WAIMATSS is a multicentre, prospective, and randomised pilot study of intravenous minocycline, 200 mg 12 hourly for 5 doses, compared with standard care, in patients with ischaemic stroke treated with intravenous tPA.
The primary endpoint is HT diagnosed by brain CT and MRI.
Secondary endpoints include clinical outcome measures.
Some illustrative cases from the early recruitment phase of this study will be presented, and future perspectives will be discussed.
American Psychological Association (APA)
Blacker, David J.& Prentice, David& Alvaro, Anthony& Bates, Timothy R.& Bynevelt, Michael& Kelly, Andrew…[et al.]. 2013. Reducing Haemorrhagic Transformation after Thrombolysis for Stroke : A Strategy Utilising Minocycline. Stroke Research and Treatment،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-466035
Modern Language Association (MLA)
Blacker, David J.…[et al.]. Reducing Haemorrhagic Transformation after Thrombolysis for Stroke : A Strategy Utilising Minocycline. Stroke Research and Treatment No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-466035
American Medical Association (AMA)
Blacker, David J.& Prentice, David& Alvaro, Anthony& Bates, Timothy R.& Bynevelt, Michael& Kelly, Andrew…[et al.]. Reducing Haemorrhagic Transformation after Thrombolysis for Stroke : A Strategy Utilising Minocycline. Stroke Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-466035
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466035