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Study of Materials for Drugs Delivery : cis-[PtCl2(NH3)2] Hydrolysis on Functionalized SiO2(100) Surfaces
Joint Authors
Simonetti, S.
Díaz Compañy, A.
Brizuela, G.
Source
Journal of Solid State Physics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The hydrolysis of the cis-platin drug on a SiO2(100) hydrated surface was investigated by computational modeling.
The cisplatin molecule presents weak interactions with the neighbouring OH groups of the hydrated surface.
The cisplatin hydrolysis is not favourable on the SiO2(100) surface.
Consequently, the adsorption properties of SiO2(100) are improved considering the surface's modification with K, Mg, or NH2 functional species.
In general, the system is more stable and the molecule-surface distance is reduced when cisplatin is adsorbed on the promoted surfaces.
The hydrolysis is a favourable process on the SiO2(100) functionalized surfaces.
The cisplatin hydrolysis is most favoured when the surface is functionalized with the NH2 specie.
The electron density exchange plays a main role in the adsorption process.
cis-[PtCl2(NH3)2] and cis-[PtCl(NH3)2]+ are adsorbed on the functionalized surface via Cl–N and Cl–Si interactions, while the cis-[Pt(NH3)2]2+ complex is adsorbed through Pt–O, Pt–Si, and Pt–H interactions.
After adsorption, the strength of the N–Si, Si–O, and N–H superficial bonds of the functionalized SiO2(100) changes favouring the interaction between the molecule and their complexes with the surface.
American Psychological Association (APA)
Díaz Compañy, A.& Brizuela, G.& Simonetti, S.. 2013. Study of Materials for Drugs Delivery : cis-[PtCl2(NH3)2] Hydrolysis on Functionalized SiO2(100) Surfaces. Journal of Solid State Physics،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-466058
Modern Language Association (MLA)
Díaz Compañy, A.…[et al.]. Study of Materials for Drugs Delivery : cis-[PtCl2(NH3)2] Hydrolysis on Functionalized SiO2(100) Surfaces. Journal of Solid State Physics No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-466058
American Medical Association (AMA)
Díaz Compañy, A.& Brizuela, G.& Simonetti, S.. Study of Materials for Drugs Delivery : cis-[PtCl2(NH3)2] Hydrolysis on Functionalized SiO2(100) Surfaces. Journal of Solid State Physics. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-466058
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466058