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Factors of the Lectin Pathway of Complement Activation and Their Clinical Associations in Neonates
Joint Authors
Swierzko, Anna St.
Cedzynski, Maciej
Kilpatrick, David C.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This paper summarizes the data concerning soluble defense lectins (mannan-binding lectin, M-ficolin, L-ficolin, and H-ficolin) with the unique ability to activate complement and their associated serine proteases (MASPs) in neonates.
The clinical importance of deficiencies of these immune factors is presented in aspects of perinatal mortality, premature births, and low birthweight.
Prenatal serum concentrations of L-ficolin, H-ficolin, and MASP-2 (and probably M-ficolin) correlate with gestational age and birthweight.
The relationship of serum MBL to gestational age is controversial.
The MBL2 genotypes XA/O and O/O (associated with low-serum MBL) are associated with perinatal infections, whereas the high serum MBL-conferring A/A genotypes may be associated with prematurity.
Low-serum L-ficolin concentrations, but not low-serum H-ficolin concentrations, are also associated with perinatal infections.
Much of the literature is inconsistent, and the relationships reported so far require independent confirmation at both gene and protein levels.
Our preliminary conclusion is that these soluble defense lectins play a protective role in the neonate, and that insufficiency of such factors contributes to the adverse consequences of prematurity and low birthweight.
American Psychological Association (APA)
Cedzynski, Maciej& Swierzko, Anna St.& Kilpatrick, David C.. 2012. Factors of the Lectin Pathway of Complement Activation and Their Clinical Associations in Neonates. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-466059
Modern Language Association (MLA)
Cedzynski, Maciej…[et al.]. Factors of the Lectin Pathway of Complement Activation and Their Clinical Associations in Neonates. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-466059
American Medical Association (AMA)
Cedzynski, Maciej& Swierzko, Anna St.& Kilpatrick, David C.. Factors of the Lectin Pathway of Complement Activation and Their Clinical Associations in Neonates. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-466059
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466059