Association between Levels of IgA Antibodies to Tissue Transglutaminase and Gliadin-Related Nonapeptides in Dermatitis Herpetiformis
Joint Authors
Seraszek-Jaros, Agnieszka
Bowszyc-Dmochowska, Monika
Kaczmarek, Elżbieta
Dmochowski, Marian
Gornowicz-Porowska, Justyna
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Dermatitis herpetiformis (DH) is an autoimmunity-driven inflammatory blistering dermatosis associated with a gluten-dependent enteropathy.
Tissue transglutaminase (tTG) and nonapeptides of gliadin (npG) are considered in its pathomechanism/diagnostics.
Here, the diagnostic accuracy of anti-tTG/anti-npG IgA ELISAs in Slavic DH patients with active skin rash was assessed through creating receiver operating characteristic (ROC) curves, determining cutoff values, and calculating correlations between levels of anti-tTG/anti-npG IgA in DH, IgA/neutrophil-mediated non-DH patients and healthy persons.
Altogether, sera from 80 Slavic individuals were examined.
There were negligible differences between cutoff points obtained by the ELISAs manufacturer and those in this study.
There were statistically significant correlations between levels of anti-tTG/anti-npG IgA in both DH group and the group of IgA/neutrophil-mediated non-DH dermatoses.
There was no such correlation in healthy controls.
It seems that IgA autoantibodies to tTG and npG in the IgA/neutrophil-mediated DH are produced in the coordinated way implying their causal relationship.
American Psychological Association (APA)
Gornowicz-Porowska, Justyna& Bowszyc-Dmochowska, Monika& Seraszek-Jaros, Agnieszka& Kaczmarek, Elżbieta& Dmochowski, Marian. 2012. Association between Levels of IgA Antibodies to Tissue Transglutaminase and Gliadin-Related Nonapeptides in Dermatitis Herpetiformis. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-466062
Modern Language Association (MLA)
Gornowicz-Porowska, Justyna…[et al.]. Association between Levels of IgA Antibodies to Tissue Transglutaminase and Gliadin-Related Nonapeptides in Dermatitis Herpetiformis. The Scientific World Journal No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-466062
American Medical Association (AMA)
Gornowicz-Porowska, Justyna& Bowszyc-Dmochowska, Monika& Seraszek-Jaros, Agnieszka& Kaczmarek, Elżbieta& Dmochowski, Marian. Association between Levels of IgA Antibodies to Tissue Transglutaminase and Gliadin-Related Nonapeptides in Dermatitis Herpetiformis. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-466062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466062