Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet’s Disease
Joint Authors
Suzuki, Noboru
Kaneko, Fumio
Shimizu, Jun
Source
Genetics Research International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Behcet’s disease (BD) is a multisystemic inflammatory disease and is characterized by recurrent attacks on eyes, brain, skin, and gut.
There is evidence that skewed T-cell responses contributed to its pathophysiology in patients with BD.
Recently, we found that Th17 cells, a new helper T (Th) cell subset, were increased in patients with BD, and both Th type 1 (Th1) and Th17 cell differentiation signaling pathways were overactivated.
Several researches revealed that genetic polymorphisms in Th1/Th17 cell differentiation signaling pathways were associated with the onset of BD.
Here, we summarize current findings on the Th cell subsets, their contribution to the pathogenesis of BD and the genetic backgrounds, especially in view of IL-12 family cytokine production and pattern recognition receptors of macrophages/monocytes.
American Psychological Association (APA)
Shimizu, Jun& Kaneko, Fumio& Suzuki, Noboru. 2013. Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet’s Disease. Genetics Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-466095
Modern Language Association (MLA)
Shimizu, Jun…[et al.]. Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet’s Disease. Genetics Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-466095
American Medical Association (AMA)
Shimizu, Jun& Kaneko, Fumio& Suzuki, Noboru. Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet’s Disease. Genetics Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-466095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466095