Imaging-Based Biomarkers : Characterization of Post-Kawasaki Vasculitis in Infants and Hypertension Phenotype in Rat Model
Joint Authors
Dahdah, Nagib
Maurice, Roch Listz
Tremblay, Johanne
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Investigating the mechanical properties of the arteries is essential in cardiovascular diseases.
Recent imaging modalities allow mapping mechanical properties within the arterial wall.
Aims.
We report the potential of imaging-based biomarker (ImBioMark) to investigate the effect of aging on the rat.
We also present preliminary data with ImBioMark characterizing vascular sequelae of Kawasaki disease (KD) in young humans.
Methods.
We investigated in vivo the effect of aging on male Brown Norway (BN) rats' (n=5) carotid stiffness.
In a second experiment, the impact of KD on the ascending aorta (AA) was examined in KD children (n=2) aged 13 ± 1.41 years old compared to KD-free children (n=5) aged 13.13 ± 0.18 years old.
Results.
The stiffness of BN's carotid artery was three times stiffer in the old rats, with a turning point at 40 weeks old (P=0.001).
KD had a very significant impact on the AA stiffness with strain estimates of 2.39 ± 0.51% versus 4.24 ± 0.65% in controls (P<0.001).
Conclusion.
ImBioMark phenotypes hypertension in rat models noninvasively in vivo without resorting to euthanasia.
Quantifying aortic wall remodeling is also feasible in humans.
Future investigations target human cardiovascular disease.
American Psychological Association (APA)
Maurice, Roch Listz& Dahdah, Nagib& Tremblay, Johanne. 2012. Imaging-Based Biomarkers : Characterization of Post-Kawasaki Vasculitis in Infants and Hypertension Phenotype in Rat Model. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-466121
Modern Language Association (MLA)
Maurice, Roch Listz…[et al.]. Imaging-Based Biomarkers : Characterization of Post-Kawasaki Vasculitis in Infants and Hypertension Phenotype in Rat Model. International Journal of Vascular Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-466121
American Medical Association (AMA)
Maurice, Roch Listz& Dahdah, Nagib& Tremblay, Johanne. Imaging-Based Biomarkers : Characterization of Post-Kawasaki Vasculitis in Infants and Hypertension Phenotype in Rat Model. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-466121
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466121