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Abnormal COX2 Protein Expression May Be Correlated with Poor Prognosis in Oral Cancer : A Meta-Analysis
Joint Authors
Liu, Hong-Bo
Zhang, Yu-Fei
Liu, Jie
Ye, Ming
Wang, Zhi-Ming
Yang, Dong-Sheng
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The prognostic significance of COX2 for survival of patients with oral cancer remains controversial.
Thus, the meta-analysis was performed in order to identify COX2 expression impact on prognosis of oral cancer.
Method.
Relevant literatures were searched using the following electronic databases without any language restrictions: Web of Science, the Cochrane Library Database, PubMed, EMBASE, CINAHL, and CBM.
Version 12.0 STATA software (Stata Corporation, College Station, Texas, USA) was used for the current meta-analysis.
Odds ratios (ORs) and hazard ratios (HRs) with their corresponding 95% confidence interval (95% CI) were also calculated to clarify the correlation between COX2 expression and prognosis of oral cancer.
Results.
Final analysis of 979 oral cancer patients from 12 clinical cohort studies was performed.
The meta-analysis results show that COX2 expression in cancer tissues was significantly higher than those in normal and benign tissues (all P < 0.05).
Combined HR of COX2 suggests that positive COX2 expression has a shorter overall survival (OS) than those of negative COX2 expression (P < 0.05).
Conclusion.
The meta-analysis study shows that elevated COX2 expression may be associated with the pathogenesis of oral cancer and with a worse prognosis in oral cancer patients.
American Psychological Association (APA)
Wang, Zhi-Ming& Liu, Jie& Liu, Hong-Bo& Ye, Ming& Zhang, Yu-Fei& Yang, Dong-Sheng. 2014. Abnormal COX2 Protein Expression May Be Correlated with Poor Prognosis in Oral Cancer : A Meta-Analysis. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-466125
Modern Language Association (MLA)
Wang, Zhi-Ming…[et al.]. Abnormal COX2 Protein Expression May Be Correlated with Poor Prognosis in Oral Cancer : A Meta-Analysis. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-466125
American Medical Association (AMA)
Wang, Zhi-Ming& Liu, Jie& Liu, Hong-Bo& Ye, Ming& Zhang, Yu-Fei& Yang, Dong-Sheng. Abnormal COX2 Protein Expression May Be Correlated with Poor Prognosis in Oral Cancer : A Meta-Analysis. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-466125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466125