Changes in Glucose and Glutamine Lymphocyte Metabolisms Induced by Type I Interferon α
Joint Authors
Bacurau, Reury F. P.
Meneguello-Coutinho, Marcela
Araújo, Ronaldo C.
Barros, Carlos C.
Almeida, Sandro S.
Moraes, Milton R.
Navarro, Francisco
Uchida, Marco C.
Wasinski, Frederick
Costa Rosa, Luís F. B.
Würtele, Martin
Vanzelli, Andréa
Bacurau, Aline V. N.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In lymphocytes (LY), the well-documented antiproliferative effects of IFN-α are associated with inhibition of protein synthesis, decreased amino acid incorporation, and cell cycle arrest.
However, the effects of this cytokine on the metabolism of glucose and glutamine in these cells have not been well investigated.
Thus, mesenteric and spleen LY of male Wistar rats were cultured in the presence or absence of IFN-α, and the changes on glucose and glutamine metabolisms were investigated.
The reduced proliferation of mesenteric LY was accompanied by a reduction in glucose total consumption (35%), aerobic glucose metabolism (55%), maximal activity of glucose-6-phosphate dehydrogenase (49%), citrate synthase activity (34%), total glutamine consumption (30%), aerobic glutamine consumption (20.3%) and glutaminase activity (56%).
In LY isolated from spleen, IFNα also reduced the proliferation and impaired metabolism.
These data demonstrate that in LY, the antiproliferative effects of IFNα are associated with a reduction in glucose and glutamine metabolisms.
American Psychological Association (APA)
Navarro, Francisco& Bacurau, Aline V. N.& Vanzelli, Andréa& Meneguello-Coutinho, Marcela& Uchida, Marco C.& Moraes, Milton R.…[et al.]. 2010. Changes in Glucose and Glutamine Lymphocyte Metabolisms Induced by Type I Interferon α. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-466138
Modern Language Association (MLA)
Navarro, Francisco…[et al.]. Changes in Glucose and Glutamine Lymphocyte Metabolisms Induced by Type I Interferon α. Mediators of Inflammation No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-466138
American Medical Association (AMA)
Navarro, Francisco& Bacurau, Aline V. N.& Vanzelli, Andréa& Meneguello-Coutinho, Marcela& Uchida, Marco C.& Moraes, Milton R.…[et al.]. Changes in Glucose and Glutamine Lymphocyte Metabolisms Induced by Type I Interferon α. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-466138
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466138