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Lack of a Y-Chromosomal Complement in the Majority of Gestational Trophoblastic Neoplasms
Joint Authors
Hafez, Michael J.
Kurman, Robert J.
Yap, Kai Lee
Murphy, Kathleen M.
Shih, Ie-Ming
Mao, Tsui-Lien
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-21
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Gestational trophoblastic neoplasms (GTNs) are a rare group of neoplastic diseases composed of choriocarcinomas, placental site trophoblastic tumors (PSTTs) and epithelioid trophoblastic tumors (ETTs).
Since these tumors are derivatives of fetal trophoblastic tissue, approximately 50% of GTN cases are expected to originate from a male conceptus and carry a Y-chromosomal complement according to a balanced sex ratio.
To investigate this hypothesis, we carried out a comprehensive analysis by genotyping a relatively large sample size of 51 GTN cases using three independent sex chromosome genetic markers; Amelogenin, Protein Kinase and Zinc Finger have X and Y homologues that are distinguishable by their PCR product size.
We found that all cases contained the X-chromosomal complement while only five (10%) of 51 tumors harbored the Y-chromosomal complement.
Specifically, Y-chromosomal signals were detected in one (5%) of 19 choriocarcinomas, one (7%) of 15 PSTTs and three (18%) of 17 ETTs.
The histopathological features of those with a Y-chromosome were similar to those without.
Our results demonstrate the presence of a Y-chromosomal complement in GTNs, albeit a low 10% of cases.
This shortfall of Y-chromosomal complements in GTNs may reinforce the notion that the majority of GTNs are derived from previous molar gestations.
American Psychological Association (APA)
Yap, Kai Lee& Hafez, Michael J.& Mao, Tsui-Lien& Kurman, Robert J.& Murphy, Kathleen M.& Shih, Ie-Ming. 2010. Lack of a Y-Chromosomal Complement in the Majority of Gestational Trophoblastic Neoplasms. Journal of Oncology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-466152
Modern Language Association (MLA)
Yap, Kai Lee…[et al.]. Lack of a Y-Chromosomal Complement in the Majority of Gestational Trophoblastic Neoplasms. Journal of Oncology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-466152
American Medical Association (AMA)
Yap, Kai Lee& Hafez, Michael J.& Mao, Tsui-Lien& Kurman, Robert J.& Murphy, Kathleen M.& Shih, Ie-Ming. Lack of a Y-Chromosomal Complement in the Majority of Gestational Trophoblastic Neoplasms. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-466152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466152