Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation : A Register-Based Nationwide Cohort Study
Joint Authors
Hjelvang, Brian Rafn
Afzal, Shoaib
Andersen, Jon Trærup
Andersen, Nadia Lyhne
Rasmussen, Jeppe Nørgaard
Jimenez-Solem, Espen
Torp-Pedersen, C.
Petersen, Morten
Køber, Lars
Poulsen, Henrik Enghusen
Broedbaek, Kasper
Source
Obstetrics and Gynecology International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
The aim of the study was to investigate whether the use of the antifolate antibiotic trimethoprim during the 12 weeks before conception was associated with congenital malformations.
Methods.
We conducted a nationwide register-based cohort study including all Danish women giving birth from 1997 to 2004.
All women with at least one prescription of trimethoprim dispensed during the 12 weeks before conception were identified.
Results.
There was a doubling of congenital malformations in offspring to women exposed to trimethoprim in the 12 weeks before conception.
The adjusted odds ratio (OR) of major congenital malformation was 1.87, 95% confidence interval (CI) 1.25–2.81.
There was a significant increase in major malformations of the heart (OR=2.49; 1.18–5.26) and limbs (OR=2.18; 1.13–4.23).
Conclusions.
In this study, we found an association between exposure to trimethoprim during the 12 weeks before conception and an increased risk of heart and limb defects.
American Psychological Association (APA)
Andersen, Jon Trærup& Petersen, Morten& Jimenez-Solem, Espen& Rasmussen, Jeppe Nørgaard& Andersen, Nadia Lyhne& Afzal, Shoaib…[et al.]. 2013. Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation : A Register-Based Nationwide Cohort Study. Obstetrics and Gynecology International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-466154
Modern Language Association (MLA)
Andersen, Jon Trærup…[et al.]. Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation : A Register-Based Nationwide Cohort Study. Obstetrics and Gynecology International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-466154
American Medical Association (AMA)
Andersen, Jon Trærup& Petersen, Morten& Jimenez-Solem, Espen& Rasmussen, Jeppe Nørgaard& Andersen, Nadia Lyhne& Afzal, Shoaib…[et al.]. Trimethoprim Use prior to Pregnancy and the Risk of Congenital Malformation : A Register-Based Nationwide Cohort Study. Obstetrics and Gynecology International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-466154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466154