Simultaneous Estimation of Ibuprofen and Phenylephrine Hydrochloride in Bulk and Combined Dosage Form by First Derivative UV Spectrophotometry Method
Joint Authors
Parmar, Shraddha J.
Patel, Mehul N.
Patel, Bhavna A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A simple, precise, rapid, and economic method was developed for the simultaneous determination of Ibuprofen and Phenylephrine HCl in bulk and combined dosage form.
This method involves first-order derivative spectroscopy using 248 nm and 237 nm as zero crossing points for Ibuprofen and Phenylephrine HCl, respectively.
For spectrophotometric method 0.1 N NaOH was used as a solvent.
The linearity was established over the concentration range of 12–72 μg/mL and 1.5–22 μg/mL for Ibuprofen and Phenylephrine HCl with correlation coefficient (r2) of 0.9972 and 0.9981, respectively.
The mean % recoveries were found to be in the range of 98.88% and 98.54% for Ibuprofen and Phenylephrine HCl, respectively.
Interday and intraday studies showed repeatability of the method.
The method was found to be specific and robust.
The method was successfully applied to pharmaceutical formulation, with no interference from excipients as indicated by the recovery study.
Results of analysis were validated statistically and by recovery studies.
American Psychological Association (APA)
Patel, Mehul N.& Patel, Bhavna A.& Parmar, Shraddha J.. 2013. Simultaneous Estimation of Ibuprofen and Phenylephrine Hydrochloride in Bulk and Combined Dosage Form by First Derivative UV Spectrophotometry Method. Journal of Spectroscopy،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466182
Modern Language Association (MLA)
Patel, Mehul N.…[et al.]. Simultaneous Estimation of Ibuprofen and Phenylephrine Hydrochloride in Bulk and Combined Dosage Form by First Derivative UV Spectrophotometry Method. Journal of Spectroscopy No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-466182
American Medical Association (AMA)
Patel, Mehul N.& Patel, Bhavna A.& Parmar, Shraddha J.. Simultaneous Estimation of Ibuprofen and Phenylephrine Hydrochloride in Bulk and Combined Dosage Form by First Derivative UV Spectrophotometry Method. Journal of Spectroscopy. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466182