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Clinical Significance of FGF-23 in Patients with CKD
Joint Authors
Russo, Domenico
Battaglia, Yuri
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
FGF23 is a bone-derived hormone that plays an important role in the regulation of phosphate and 1,25-dihydroxy vitamin D metabolism.
FGF23 principally acts in the kidney to induce urinary phosphate excretion and suppress 1,25-dihydroxyvitamin D synthesis in the presence of FGF receptor 1 (FGFR1) and its coreceptor Klotho.
In patients with chronic kidney disease (CKD), circulating FGF23 levels are progressively increased to compensate for persistent phosphate retention, but this results in reduced renal production of 1,25-dihydroxyvitamin D and leads to hypersecretion of parathyroid hormone.
Furthermore, FGF23 is associated with vascular dysfunction, atherosclerosis, and left ventricular hypertrophy.
This paper summarizes the role of FGF23 in the pathogenesis of mineral, bone, and cadiovascular disorders in CKD.
American Psychological Association (APA)
Russo, Domenico& Battaglia, Yuri. 2011. Clinical Significance of FGF-23 in Patients with CKD. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-466193
Modern Language Association (MLA)
Russo, Domenico& Battaglia, Yuri. Clinical Significance of FGF-23 in Patients with CKD. International Journal of Nephrology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-466193
American Medical Association (AMA)
Russo, Domenico& Battaglia, Yuri. Clinical Significance of FGF-23 in Patients with CKD. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-466193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466193