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Progress in Personalizing Chemotherapy for Bladder Cancer
Joint Authors
Chang, James S.
Pan, Chong-Xian
Lara, Primo N.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Platinum-based chemotherapy is commonly used for the treatment of locally advanced and metastatic bladder cancer.
However, there are currently no methods to predict chemotherapy response in this disease setting.
A better understanding of the biology of bladder cancer has led to developments of molecular biomarkers that may help guide clinical decision making.
These biomarkers, while promising, have not yet been validated in prospective trials and are not ready for clinical applications.
As alkylating agents, platinum drugs kill cancer cells mainly through induction of DNA damage.
A microdosing approach is currently being tested to determine if chemoresistance can be identified by measuring platinum-induced DNA damage using highly sensitive accelerator mass spectrometry technology.
The hope is that these emerging strategies will help pave the road towards personalized therapy in advanced bladder cancer.
American Psychological Association (APA)
Chang, James S.& Lara, Primo N.& Pan, Chong-Xian. 2012. Progress in Personalizing Chemotherapy for Bladder Cancer. Advances in Urology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-466197
Modern Language Association (MLA)
Chang, James S.…[et al.]. Progress in Personalizing Chemotherapy for Bladder Cancer. Advances in Urology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-466197
American Medical Association (AMA)
Chang, James S.& Lara, Primo N.& Pan, Chong-Xian. Progress in Personalizing Chemotherapy for Bladder Cancer. Advances in Urology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-466197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466197