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Cytokines and Their Roles in the Pathogenesis of Systemic Lupus Erythematosus : From Basics to Recent Advances
Joint Authors
Yap, Desmond Yat Hin
Lai, Kar Neng
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is a complex auto-immune disorder which involves various facets of the immune system.
In addition to autoantibody production and immune complex deposition, emerging evidences suggest that cytokines may act as key players in the immunopathogenesis of SLE.
These cytokines assume a critical role in the differentiation, maturation and activation of cells and also participate in the local inflammatory processes that mediate tissue insults in SLE.
Certain cytokines such as the IL-6, IL-10, IL-17, BLys, type I interferons (IFN) and tumor necrosis factor-α (TNF-α) are closely linked to pathogenesis of SLE.
The delineation of the role played by these cytokines not only fosters our understanding of this disease but also provides a sound rationale for various therapeutic approaches.
In this context, this review focuses on selected cytokines which exert significant effect in the pathogenesis of SLE and their possible clinical applications.
American Psychological Association (APA)
Yap, Desmond Yat Hin& Lai, Kar Neng. 2010. Cytokines and Their Roles in the Pathogenesis of Systemic Lupus Erythematosus : From Basics to Recent Advances. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-466213
Modern Language Association (MLA)
Yap, Desmond Yat Hin& Lai, Kar Neng. Cytokines and Their Roles in the Pathogenesis of Systemic Lupus Erythematosus : From Basics to Recent Advances. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-466213
American Medical Association (AMA)
Yap, Desmond Yat Hin& Lai, Kar Neng. Cytokines and Their Roles in the Pathogenesis of Systemic Lupus Erythematosus : From Basics to Recent Advances. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-466213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466213