Potential Application of Cord Blood-Derived Stromal Cells in Cellular Therapy and Regenerative Medicine
Joint Authors
Kogler, Gesine
Radke, Teja Falk
Kluth, Simone Maria
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Neonatal stromal cells from umbilical cord blood (CB) are promising alternatives to bone marrow- (BM-) derived multipotent stromal cells (MSCs).
In comparison to BM-MSC, the less mature CB-derived stromal cells have been described as a cell population with higher differentiation and proliferation potential that might be of potential interest for clinical application in regenerative medicine.
Recently, it has become clear that cord blood contains different stromal cell populations, and as of today, a clear distinction between unrestricted somatic stromal cells (USSCs) and CB-MSC has been established.
This classification is based on the expression of DLK-1, HOX, and CD146, as well as functional examination of the adipogenic differentiation potential and the capacity to support haematopoiesis in vitro and in vivo.
However, a marker enabling a prospective isolation of the rare cell populations directly out of cord blood is yet to be found.
Further analysis may help to reveal even more subpopulations with different properties, which could be useful for the directed application of these cells in preclinical models.
American Psychological Association (APA)
Kluth, Simone Maria& Radke, Teja Falk& Kogler, Gesine. 2012. Potential Application of Cord Blood-Derived Stromal Cells in Cellular Therapy and Regenerative Medicine. Journal of Blood Transfusion،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-466226
Modern Language Association (MLA)
Kluth, Simone Maria…[et al.]. Potential Application of Cord Blood-Derived Stromal Cells in Cellular Therapy and Regenerative Medicine. Journal of Blood Transfusion No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-466226
American Medical Association (AMA)
Kluth, Simone Maria& Radke, Teja Falk& Kogler, Gesine. Potential Application of Cord Blood-Derived Stromal Cells in Cellular Therapy and Regenerative Medicine. Journal of Blood Transfusion. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-466226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466226