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RASSF1 Polymorphisms in Cancer
Joint Authors
El-Kalla, Mohamed
Baksh, Shairaz
Gordon, Marilyn
Source
Molecular Biology International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Ras association domain family 1A (RASSF1A) is one of the most epigenetically silenced elements in human cancers.
Localized on chromosome 3, it has been demonstrated to be a bone fide tumor suppressor influencing cell cycle events, microtubule stability, apoptosis, and autophagy.
Although it is epigenetically silenced by promoter-specific methylation in cancers, several somatic nucleotide changes (polymorphisms) have been identified in RASSF1A in tissues from cancer patients.
We speculate that both nucleotide changes and epigenetic silencing result in loss of the RASSF1A tumor suppressor function and the appearance of enhanced growth.
This paper will summarize what is known about the origin of these polymorphisms and how they have helped us understand the biological role of RASSF1A.
American Psychological Association (APA)
Gordon, Marilyn& El-Kalla, Mohamed& Baksh, Shairaz. 2012. RASSF1 Polymorphisms in Cancer. Molecular Biology International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-466231
Modern Language Association (MLA)
Gordon, Marilyn…[et al.]. RASSF1 Polymorphisms in Cancer. Molecular Biology International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-466231
American Medical Association (AMA)
Gordon, Marilyn& El-Kalla, Mohamed& Baksh, Shairaz. RASSF1 Polymorphisms in Cancer. Molecular Biology International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-466231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466231