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Evaluation of Chromosomal Instability in Diabetic Rats Treated with Naringin
Joint Authors
M. Attia, Sabry
Bakheet, Saleh A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
We used the bone marrow DNA strand breaks, micronucleus formations, spermatocyte chromosomal aberrations, and sperm characteristic assays to investigate the chromosomal instability in somatic and germinal cells of diabetic rats treated with multiple doses of naringin.
The obtained results revealed that naringin was neither cytotoxic nor genotoxic for the rats at all tested doses.
Moreover, naringin significantly reduced the diabetes-induced chromosomal instability in somatic and germinal cells in a dose-dependent manner.
In addition, diabetes induced marked biochemical alterations characteristic of oxidative stress including enhanced lipid peroxidation, accumulation of oxidized glutathione, reduction in reduced glutathione, and accumulation of intracellular reactive oxygen species.
Treatment with naringin ameliorated these biochemical markers dose-dependently.
In conclusion, naringin confers an appealing protective effect against diabetes-induced chromosomal instability towards rat somatic and germinal cells which might be explained partially via diminishing the de novo free radical generation induced by hyperglycemia.
Thus, naringin might be a good candidate to reduce genotoxic risk associated with hyperglycemia and may provide decreases in the development of secondary malignancy and abnormal reproductive outcomes risks, which seems especially important for diabetic patients.
American Psychological Association (APA)
Bakheet, Saleh A.& M. Attia, Sabry. 2011. Evaluation of Chromosomal Instability in Diabetic Rats Treated with Naringin. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-466241
Modern Language Association (MLA)
Bakheet, Saleh A.& M. Attia, Sabry. Evaluation of Chromosomal Instability in Diabetic Rats Treated with Naringin. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-466241
American Medical Association (AMA)
Bakheet, Saleh A.& M. Attia, Sabry. Evaluation of Chromosomal Instability in Diabetic Rats Treated with Naringin. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-466241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466241