The Effect of Edge Definition of Complex Networks on Protein Structure Identification
Joint Authors
Li, Menglong
Wu, Di
Li, Yizhou
Sun, Jing
Jing, Runyu
Zhu, Tuanfei
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The main objective of this study is to explore the contribution of complex network together with its different definitions of vertexes and edges to describe the structure of proteins.
Protein folds into a specific conformation for its function depending on interactions between residues.
Consequently, in many studies, a protein structure was treated as a complex system comprised of individual components residues, and edges were interactions between residues.
What is the proper time for representing a protein structure as a network? To confirm the effect of different definitions of vertexes and edges in constructing the amino acid interaction networks, protein domains and the structural unit of proteins were described using this method.
The identification performance of 2847 proteins with domain/domains proved that the structure of proteins was described well when RCα was around 5.0–7.5 Å, and the optimal cutoff value for constructing the protein structure networks was 5.0 Å (Cα-Cα distances) while the ideal community division method was community structure detection based on edge betweenness in this study.
American Psychological Association (APA)
Sun, Jing& Jing, Runyu& Wu, Di& Zhu, Tuanfei& Li, Menglong& Li, Yizhou. 2013. The Effect of Edge Definition of Complex Networks on Protein Structure Identification. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-466254
Modern Language Association (MLA)
Sun, Jing…[et al.]. The Effect of Edge Definition of Complex Networks on Protein Structure Identification. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-466254
American Medical Association (AMA)
Sun, Jing& Jing, Runyu& Wu, Di& Zhu, Tuanfei& Li, Menglong& Li, Yizhou. The Effect of Edge Definition of Complex Networks on Protein Structure Identification. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-466254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466254