Reconstruction-Dependent Recovery from Anorexia and Time-Related Recovery of Regulatory Ghrelin System in Gastrectomized Rats
Joint Authors
Yasuda, Yoshikazu
Kobayashi, Eiji
Dezaki, Katsuya
Koizumi, Masaru
Hosoya, Yoshinori
Sata, Naohiro
Ming, Lu
Yada, Toshihiko
Damdindorj, Boldbaatar
Hosoda, Hiroshi
Nagai, Hideo
Sone, Hideyuki
Kangawa, Kenji
Source
International Journal of Peptides
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Gastrectomy reduces food intake and body weight (BW) hampering recovery of physical conditions.
It also reduces plasma levels of stomach-derived orexigenic ghrelin.
This study explored changes in orexigenic ghrelin system in rats receiving total gastrectomy with Billroth II (B-II) or Roux-en-Y (R-Y) method.
Feeding and BW were reduced by gastrectomy and subsequently recovered to a greater extent with R-Y than B-II while plasma ghrelin decreased similarly.
At postoperative 12th week, ghrelin contents increased in the duodenum and pancreas, plasma ghrelin levels increased upon fasting, and ghrelin injection promoted feeding but not in earlier periods.
In summary, gastrectomized rats partially recover feeding and BW, in a reconstruction-dependent manner.
At 12th week, ghrelin is upregulated in extra-stomach tissues, plasma ghrelin levels are physiologically regulated, and orexigenic effect of exogenous ghrelin is restored.
This time-related recovery of ghrelin system may provide a strategy for promoting feeding, BW, and thereby physical conditions in gastrectomized patients.
American Psychological Association (APA)
Koizumi, Masaru& Dezaki, Katsuya& Hosoda, Hiroshi& Damdindorj, Boldbaatar& Sone, Hideyuki& Ming, Lu…[et al.]. 2010. Reconstruction-Dependent Recovery from Anorexia and Time-Related Recovery of Regulatory Ghrelin System in Gastrectomized Rats. International Journal of Peptides،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-466256
Modern Language Association (MLA)
Koizumi, Masaru…[et al.]. Reconstruction-Dependent Recovery from Anorexia and Time-Related Recovery of Regulatory Ghrelin System in Gastrectomized Rats. International Journal of Peptides No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-466256
American Medical Association (AMA)
Koizumi, Masaru& Dezaki, Katsuya& Hosoda, Hiroshi& Damdindorj, Boldbaatar& Sone, Hideyuki& Ming, Lu…[et al.]. Reconstruction-Dependent Recovery from Anorexia and Time-Related Recovery of Regulatory Ghrelin System in Gastrectomized Rats. International Journal of Peptides. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-466256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466256