![](/images/graphics-bg.png)
Fatty Acid Oxidation and Cardiovascular Risk during Menopause : A Mitochondrial Connection?
Joint Authors
Sardao, Vilma A.
Bonfrate, Leonilde
Carvalho, Rui A.
Oliveira, Paulo J.
Portincasa, Piero
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Menopause is a consequence of the normal aging process in women.
This fact implies that the physiological and biochemical alterations resulting from menopause often blur with those from the aging process.
It is thought that menopause in women presents a higher risk for cardiovascular disease although the precise mechanism is still under discussion.
The postmenopause lipid profile is clearly altered, which can present a risk factor for cardiovascular disease.
Due to the role of mitochondria in fatty acid oxidation, alterations of the lipid profile in the menopausal women will also influence mitochondrial fatty acid oxidation fluxes in several organs.
In this paper, we propose that alterations of mitochondrial bioenergetics in the heart, consequence from normal aging and/or from the menopausal process, result in decreased fatty acid oxidation and accumulation of fatty acid intermediates in the cardiomyocyte cytosol, resulting in lipotoxicity and increasing the cardiovascular risk in the menopausal women.
American Psychological Association (APA)
Oliveira, Paulo J.& Carvalho, Rui A.& Portincasa, Piero& Bonfrate, Leonilde& Sardao, Vilma A.. 2012. Fatty Acid Oxidation and Cardiovascular Risk during Menopause : A Mitochondrial Connection?. Journal of Lipids،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-466289
Modern Language Association (MLA)
Oliveira, Paulo J.…[et al.]. Fatty Acid Oxidation and Cardiovascular Risk during Menopause : A Mitochondrial Connection?. Journal of Lipids No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-466289
American Medical Association (AMA)
Oliveira, Paulo J.& Carvalho, Rui A.& Portincasa, Piero& Bonfrate, Leonilde& Sardao, Vilma A.. Fatty Acid Oxidation and Cardiovascular Risk during Menopause : A Mitochondrial Connection?. Journal of Lipids. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-466289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466289