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Magnolia Extract (BL153) Ameliorates Kidney Damage in a High Fat Diet-Induced Obesity Mouse Model
Joint Authors
Kim, Ki-Soo
Cui, Wen-peng
Cai, Lu
Wang, Yang-wei
Kim, Ki Ho
Tan, Yi
Kim, Young Heui
Sun, Weixia
Chen, Qiang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Accumulating evidence demonstrated that obesity is a risk factor for renal structural and functional changes, leading to the end-stage renal disease which imposes a heavy economic burden on the community.
However, no effective therapeutic method for obesity-associated kidney disease is available.
In the present study, we explored the therapeutic potential of a magnolia extract (BL153) for treating obesity-associated kidney damage in a high fat diet- (HFD-) induced mouse model.
The results showed that inflammation markers (tumor necrosis factor-α and plasminogen activator inhibitor-1) and oxidative stress markers (3-nitrotyrosine and 4-hydroxy-2-nonenal) were all significantly increased in the kidney of HFD-fed mice compared to mice fed with a low fat diet (LFD).
Additionally, proteinuria and renal structure changes in HFD-fed mice were much more severe than that in LFD-fed mice.
However, all these alterations were attenuated by BL153 treatment, accompanied by upregulation of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) and hexokinase II (HK II) expression in the kidney.
The present study indicates that BL153 administration may be a novel approach for renoprotection in obese individuals by antiinflammation and anti-oxidative stress most likely via upregulation of PGC-1α and HK II signal in the kidney.
American Psychological Association (APA)
Cui, Wen-peng& Wang, Yang-wei& Chen, Qiang& Sun, Weixia& Cai, Lu& Tan, Yi…[et al.]. 2013. Magnolia Extract (BL153) Ameliorates Kidney Damage in a High Fat Diet-Induced Obesity Mouse Model. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-466311
Modern Language Association (MLA)
Cui, Wen-peng…[et al.]. Magnolia Extract (BL153) Ameliorates Kidney Damage in a High Fat Diet-Induced Obesity Mouse Model. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-466311
American Medical Association (AMA)
Cui, Wen-peng& Wang, Yang-wei& Chen, Qiang& Sun, Weixia& Cai, Lu& Tan, Yi…[et al.]. Magnolia Extract (BL153) Ameliorates Kidney Damage in a High Fat Diet-Induced Obesity Mouse Model. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-466311
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466311