Role of Mitogen-Activated Protein Kinase Pathways in Multifactorial Adverse Cardiac Remodeling Associated with Metabolic Syndrome
Joint Authors
Dallegri, Franco
Quercioli, Alessandra
Montecucco, Fabrizio
Mach, François
Nencioni, Alessio
Asrih, Mohamed
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Metabolic syndrome has been widely associated with an increased risk for acute cardiovascular events.
Emerging evidence supports metabolic syndrome as a condition favoring an adverse cardiac remodeling, which might evolve towards heart dysfunction and failure.
This pathological remodeling has been described to result from the cardiac adaptive response to clinical mechanical conditions (such as hypertension, dyslipidemia, and hyperglycemia), soluble inflammatory molecules (such as cytokines and chemokines), as well as hormones (such as insulin), characterizing the pathophysiology of metabolic syndrome.
Moreover, these cardiac processes (resulting in cardiac hypertrophy and fibrosis) are also associated with the modulation of intracellular signalling pathways within cardiomyocytes.
Amongst the different intracellular kinases, mitogen-activated protein kinases (MAPKs) were shown to be involved in heart damage in metabolic syndrome.
However, their role remains controversial.
In this paper, we will discuss and update evidence on MAPK-mediated mechanisms underlying cardiac adverse remodeling associated with metabolic syndrome.
American Psychological Association (APA)
Asrih, Mohamed& Mach, François& Nencioni, Alessio& Dallegri, Franco& Quercioli, Alessandra& Montecucco, Fabrizio. 2013. Role of Mitogen-Activated Protein Kinase Pathways in Multifactorial Adverse Cardiac Remodeling Associated with Metabolic Syndrome. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-466335
Modern Language Association (MLA)
Asrih, Mohamed…[et al.]. Role of Mitogen-Activated Protein Kinase Pathways in Multifactorial Adverse Cardiac Remodeling Associated with Metabolic Syndrome. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-466335
American Medical Association (AMA)
Asrih, Mohamed& Mach, François& Nencioni, Alessio& Dallegri, Franco& Quercioli, Alessandra& Montecucco, Fabrizio. Role of Mitogen-Activated Protein Kinase Pathways in Multifactorial Adverse Cardiac Remodeling Associated with Metabolic Syndrome. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-466335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466335