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Hydralazine Reverses Stress-Induced Elevations in Blood Pressure, Angiotensin II, Testosterone, and Coronary Pathology in a Social Colony Model
Joint Authors
Li, Changying
Salisbury, Ron
Ely, Daniel
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The vasodilator hydralazine (HYZ) has been used successfully to lower blood pressure (BP) in hypertension.
Recently proposed novel mechanisms suggest it may be an important drug in reducing cardiovascular pathology.
Methods.
The hypothesis was that social stress would increase BP and endocrine factors that lead to increased coronary artery collagen deposition, and that HYZ treatment would reverse these changes.
SHR males were compared: controls, colony stress and colony stress with HYZ treatment.
Results.
BP was significantly elevated in the stress group compared to controls and HYZ reduced the BP compared to controls.
Plasma Ang II and T were significantly increased by colony stress compared to controls and HYZ restored both to control values.
Collagen deposition in the coronary artery was increased in the colony stress group compared to controls but HYZ treatment restored the collagen to that of control values.
Conclusions.
HYZ reduced not only BP, but also reduced coronary adventitial collagen.
The mechanism of the BP effect is most likely through vasodilation and the collagen reduction may be due to both a direct action of HYZ on collagen synthetic enzymes and indirectly through an effect of testosterone and angiotensin II.
American Psychological Association (APA)
Li, Changying& Salisbury, Ron& Ely, Daniel. 2011. Hydralazine Reverses Stress-Induced Elevations in Blood Pressure, Angiotensin II, Testosterone, and Coronary Pathology in a Social Colony Model. ISRN Pathology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-466341
Modern Language Association (MLA)
Li, Changying…[et al.]. Hydralazine Reverses Stress-Induced Elevations in Blood Pressure, Angiotensin II, Testosterone, and Coronary Pathology in a Social Colony Model. ISRN Pathology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-466341
American Medical Association (AMA)
Li, Changying& Salisbury, Ron& Ely, Daniel. Hydralazine Reverses Stress-Induced Elevations in Blood Pressure, Angiotensin II, Testosterone, and Coronary Pathology in a Social Colony Model. ISRN Pathology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-466341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466341