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Tissue Factor, Blood Coagulation, and Beyond : An Overview
Author
Source
International Journal of Inflammation
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-30, 30 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-20
Country of Publication
Egypt
No. of Pages
30
Main Subjects
Abstract EN
Emerging evidence shows a broad spectrum of biological functions of tissue factor (TF).
TF classical role in initiating the extrinsic blood coagulation and its direct thrombotic action in close relation to cardiovascular risks have long been established.
TF overexpression/hypercoagulability often observed in many clinical conditions certainly expands its role in proinflammation, diabetes, obesity, cardiovascular diseases, angiogenesis, tumor metastasis, wound repairs, embryonic development, cell adhesion/migration, innate immunity, infection, pregnancy loss, and many others.
This paper broadly covers seminal observations to discuss TF pathogenic roles in relation to diverse disease development or manifestation.
Biochemically, extracellular TF signaling interfaced through protease-activated receptors (PARs) elicits cellular activation and inflammatory responses.
TF diverse biological roles are associated with either coagulation-dependent or noncoagulation-mediated actions.
Apparently, TF hypercoagulability refuels a coagulation-inflammation-thrombosis circuit in “autocrine” or “paracrine” fashions, which triggers a wide spectrum of pathophysiology.
Accordingly, TF suppression, anticoagulation, PAR blockade, or general anti-inflammation offers an array of therapeutical benefits for easing diverse pathological conditions.
American Psychological Association (APA)
Chu, Arthur J.. 2011. Tissue Factor, Blood Coagulation, and Beyond : An Overview. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-30.
https://search.emarefa.net/detail/BIM-466342
Modern Language Association (MLA)
Chu, Arthur J.. Tissue Factor, Blood Coagulation, and Beyond : An Overview. International Journal of Inflammation No. 2011 (2011), pp.1-30.
https://search.emarefa.net/detail/BIM-466342
American Medical Association (AMA)
Chu, Arthur J.. Tissue Factor, Blood Coagulation, and Beyond : An Overview. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-30.
https://search.emarefa.net/detail/BIM-466342
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466342