Cardiovascular Involvement in Autoimmune Diseases
Joint Authors
Rojas-Villarraga, Adriana
Amaya-Amaya, Jenny
Montoya-Sánchez, Laura
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-31, 31 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-21
Country of Publication
Egypt
No. of Pages
31
Main Subjects
Abstract EN
Autoimmune diseases (AD) represent a broad spectrum of chronic conditions that may afflict specific target organs or multiple systems with a significant burden on quality of life.
These conditions have common mechanisms including genetic and epigenetics factors, gender disparity, environmental triggers, pathophysiological abnormalities, and certain subphenotypes.
Atherosclerosis (AT) was once considered to be a degenerative disease that was an inevitable consequence of aging.
However, research in the last three decades has shown that AT is not degenerative or inevitable.
It is an autoimmune-inflammatory disease associated with infectious and inflammatory factors characterized by lipoprotein metabolism alteration that leads to immune system activation with the consequent proliferation of smooth muscle cells, narrowing arteries, and atheroma formation.
Both humoral and cellular immune mechanisms have been proposed to participate in the onset and progression of AT.
Several risk factors, known as classic risk factors, have been described.
Interestingly, the excessive cardiovascular events observed in patients with ADs are not fully explained by these factors.
Several novel risk factors contribute to the development of premature vascular damage.
In this review, we discuss our current understanding of how traditional and nontraditional risk factors contribute to pathogenesis of CVD in AD.
American Psychological Association (APA)
Amaya-Amaya, Jenny& Montoya-Sánchez, Laura& Rojas-Villarraga, Adriana. 2014. Cardiovascular Involvement in Autoimmune Diseases. BioMed Research International،Vol. 2014, no. 2014, pp.1-31.
https://search.emarefa.net/detail/BIM-466350
Modern Language Association (MLA)
Amaya-Amaya, Jenny…[et al.]. Cardiovascular Involvement in Autoimmune Diseases. BioMed Research International No. 2014 (2014), pp.1-31.
https://search.emarefa.net/detail/BIM-466350
American Medical Association (AMA)
Amaya-Amaya, Jenny& Montoya-Sánchez, Laura& Rojas-Villarraga, Adriana. Cardiovascular Involvement in Autoimmune Diseases. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-31.
https://search.emarefa.net/detail/BIM-466350
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466350