Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer
Joint Authors
Stravodimou, Athina
Mazzoccoli, Gianluigi
Voutsadakis, Ioannis A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Pancreatic cancer is one of the most lethal forms of human cancer.
Although progress in oncology has improved outcomes in many forms of cancer, little progress has been made in pancreatic carcinoma and the prognosis of this malignancy remains grim.
Several molecular abnormalities often present in pancreatic cancer have been defined and include mutations in K-ras, p53, p16, and DPC4 genes.
Nuclear receptor Peroxisome Proliferator-Activated Receptor gamma (PPARγ) has a role in many carcinomas and has been found to be overexpressed in pancreatic cancer.
It plays generally a tumor suppressor role antagonizing proteins promoting carcinogenesis such as NF-κB and TGFβ.
Regulation of pathways involved in pancreatic carcinogenesis is effectuated by the Ubiquitin Proteasome System (UPS).
This paper will examine PPARγ in pancreatic cancer, the regulation of this nuclear receptor by the UPS, and their relationship to other pathways important in pancreatic carcinogenesis.
American Psychological Association (APA)
Stravodimou, Athina& Mazzoccoli, Gianluigi& Voutsadakis, Ioannis A.. 2012. Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer. PPAR Research،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-466355
Modern Language Association (MLA)
Stravodimou, Athina…[et al.]. Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer. PPAR Research No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-466355
American Medical Association (AMA)
Stravodimou, Athina& Mazzoccoli, Gianluigi& Voutsadakis, Ioannis A.. Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-466355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466355