Effects of Nebivolol on Endothelial Gene Expression during Oxidative Stress in Human Umbilical Vein Endothelial Cells
Joint Authors
Fratta Pasini, Anna
Cominacini, Mattia
Manfro, Stefania
Garbin, Ulisse
Cominacini, Luciano
Evangelista, Stefano
Stranieri, Chiara
Boccioletti, Veronica
Mozzini, Chiara
Pasini, Andrea
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-04-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The endothelium plays a key role in the development of atherogenesis and its inflammatory and proliferative status influences the progression of atherosclerosis.
The aim of this study is to compare the effects of two beta blockers such as nebivolol and atenolol on gene expression in human umbilical vein endothelial cells (HUVECs) following an oxidant stimulus.
HUVECs were incubated with nebivolol or atenolol (10 micromol/L) for 24 hours and oxidative stress was induced by the addition of oxidized (ox)-LDL.
Ox-LDL upregulated adhesion molecules (ICAM-1, ICAM-2, ICAM-3, E-selectin, and P-selectin); proteins linked to inflammation (IL-6 and TNFalpha), thrombotic state (tissue factor, PAI-1 and uPA), hypertension such as endothelin-1 (ET-1), and vascular remodeling such as metalloproteinases (MMP-2, MMP-9) and protease inhibitor (TIMP-1).
The exposure of HUVECs to nebivolol, but not to atenolol, reduced these genes upregulated by oxidative stress both in terms of protein and RNA expression.
The known antioxidant properties of the third generation beta blocker nebivolol seem to account to the observed differences seen when compared to atenolol and support the specific potential protective role of this beta blocker on the expression of a number of genes involved in the initiation and progression of atherosclerosis.
American Psychological Association (APA)
Garbin, Ulisse& Fratta Pasini, Anna& Stranieri, Chiara& Manfro, Stefania& Mozzini, Chiara& Boccioletti, Veronica…[et al.]. 2008. Effects of Nebivolol on Endothelial Gene Expression during Oxidative Stress in Human Umbilical Vein Endothelial Cells. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-466376
Modern Language Association (MLA)
Garbin, Ulisse…[et al.]. Effects of Nebivolol on Endothelial Gene Expression during Oxidative Stress in Human Umbilical Vein Endothelial Cells. Mediators of Inflammation No. 2008 (2008), pp.1-6.
https://search.emarefa.net/detail/BIM-466376
American Medical Association (AMA)
Garbin, Ulisse& Fratta Pasini, Anna& Stranieri, Chiara& Manfro, Stefania& Mozzini, Chiara& Boccioletti, Veronica…[et al.]. Effects of Nebivolol on Endothelial Gene Expression during Oxidative Stress in Human Umbilical Vein Endothelial Cells. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-6.
https://search.emarefa.net/detail/BIM-466376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466376