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Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N-Diethyl-Substituted Amido Moieties
Joint Authors
Familoni, Oluwole B.
Wu, Feipeng
Ajani, Olayinka O.
Sujiang, Zheng
Echeme, Johnbull O.
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities.
We have synthesized a series of α-tolylsulfonamide, 1–11 and their substituted N,N-diethyl-2-(phenylmethylsulfonamido) alkanamide derivatives, 12–22 in improved and excellent yields in aqueous medium at room temperature through highly economical synthetic routes.
The chemical structures of the synthesized compounds 1–22 were confirmed by analytical and spectral data such as IR, 1H- and 13C-NMR, and mass spectra.
The in vitro antibacterial activity of these compounds along with standard clinical reference, streptomycin, was investigated on two key targeted organisms.
It was observed that 1-(benzylsulfonyl)pyrrolidine-2-carboxylic acid, 2 emerged as the most active compound against Staphylococcus aureus at MIC value of 1.8 μg/mL while 4-(3-(diethylamino)-3-oxo-2-(phenylmethylsulfonamido) propyl)phenyl phenylmethanesulfonate, 22 was the most active sulfonamide scaffold on Escherichia coli at MIC value of 12.5 μg/mL.
American Psychological Association (APA)
Ajani, Olayinka O.& Familoni, Oluwole B.& Wu, Feipeng& Echeme, Johnbull O.& Sujiang, Zheng. 2012. Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N-Diethyl-Substituted Amido Moieties. International Journal of Medicinal Chemistry،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-466388
Modern Language Association (MLA)
Ajani, Olayinka O.…[et al.]. Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N-Diethyl-Substituted Amido Moieties. International Journal of Medicinal Chemistry No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-466388
American Medical Association (AMA)
Ajani, Olayinka O.& Familoni, Oluwole B.& Wu, Feipeng& Echeme, Johnbull O.& Sujiang, Zheng. Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N-Diethyl-Substituted Amido Moieties. International Journal of Medicinal Chemistry. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-466388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466388