Chronic Heat Stress Weakened the Innate Immunity and Increased the Virulence of Highly Pathogenic Avian Influenza Virus H5N1 in Mice
Joint Authors
Hu, Yanxin
Wang, Ming
Han, Deping
Jin, Yi
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chronic heat stress (CHS) can negatively affect immune response in animals.
In this study we assessed the effects of CHS on host innate immunity and avian influenza virus H5N1 infection in mice.
Mice were divided into two groups: CHS and thermally neutral (TN).
The CHS treatment group exhibited reduced local immunity in the respiratory tract, including the number of pulmonary alveolar macrophages and lesions in the nasal mucosa, trachea, and lungs.
Meanwhile, CHS retarded dendritic cells (DCs) maturation and reduced the mRNA levels of IL-6 and IFN-β significantly (P<.05).
After the CHS treatment, mice were infected with H5N1 virus.
The mortality rate and viral load in the lungs of CHS group were higher than those of TN group.
The results suggest that the CHS treatment could suppress local immunity in the respiratory tract and innate host immunity in mice significantly and moderately increased the virulence in H5N1-infected mice.
American Psychological Association (APA)
Jin, Yi& Hu, Yanxin& Han, Deping& Wang, Ming. 2011. Chronic Heat Stress Weakened the Innate Immunity and Increased the Virulence of Highly Pathogenic Avian Influenza Virus H5N1 in Mice. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-466392
Modern Language Association (MLA)
Jin, Yi…[et al.]. Chronic Heat Stress Weakened the Innate Immunity and Increased the Virulence of Highly Pathogenic Avian Influenza Virus H5N1 in Mice. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-466392
American Medical Association (AMA)
Jin, Yi& Hu, Yanxin& Han, Deping& Wang, Ming. Chronic Heat Stress Weakened the Innate Immunity and Increased the Virulence of Highly Pathogenic Avian Influenza Virus H5N1 in Mice. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-466392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466392