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Molecular Regulation of the Mitochondrial F1Fo-ATPsynthase : Physiological and Pathological Significance of the Inhibitory Factor 1 (IF1)
Joint Authors
Faccenda, Danilo
Campanella, Michelangelo
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In mammals, the mitochondrial F1Fo-ATPsynthase sets out the energy homeostasis by producing the bulk of cellular ATP.
As for every enzyme, the laws of thermodynamics command it; however, it is privileged to have a dedicated molecular regulator that controls its rotation.
This is the so-called ATPase Inhibitory Factor 1 (IF1) that blocks its reversal to avoid the consumption of cellular ATP when the enzyme acts as an ATP hydrolase.
Recent evidence has also demonstrated that IF1 may control the alignment of the enzyme along the mitochondrial inner membrane, thus increasing the interest for the molecule.
We conceived this review to outline the fundamental knowledge of the F1Fo-ATPsynthase and link it to the molecular mechanisms by which IF1 regulates its way of function, with the ultimate goal to highlight this as an important and possibly unique means to control this indispensable enzyme in both physiological and pathological settings.
American Psychological Association (APA)
Faccenda, Danilo& Campanella, Michelangelo. 2012. Molecular Regulation of the Mitochondrial F1Fo-ATPsynthase : Physiological and Pathological Significance of the Inhibitory Factor 1 (IF1). International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-466402
Modern Language Association (MLA)
Faccenda, Danilo& Campanella, Michelangelo. Molecular Regulation of the Mitochondrial F1Fo-ATPsynthase : Physiological and Pathological Significance of the Inhibitory Factor 1 (IF1). International Journal of Cell Biology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-466402
American Medical Association (AMA)
Faccenda, Danilo& Campanella, Michelangelo. Molecular Regulation of the Mitochondrial F1Fo-ATPsynthase : Physiological and Pathological Significance of the Inhibitory Factor 1 (IF1). International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-466402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466402