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Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension : A Retrospective Analysis
Joint Authors
Jansen, Pieter M.
Verdonk, Koen
Imholz, Ben P.
van den Meiracker, Anton H.
Jan Danser, A. H.
Source
International Journal of Hypertension
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
The long-term efficacy of aldosterone-receptor antagonists (ARAs) as add-on treatment in uncontrolled hypertension has not yet been reported.
Methods.
Data from 123 patients (21 with primary aldosteronism, 102 with essential hypertension) with difficult-to-treat hypertension who received an ARA between May 2005 and September 2009 were analyzed retrospectively for their blood pressure (BP) and biochemical response at first followup after start with ARA and the last follow-up available.
Results.
Systolic BP decreased by 22±20 and diastolic BP by 9.4±12 mmHg after a median treatment duration of 25 months.
In patients that received treatment >5 years, SBP was 33±20 and DBP was 16 ± 13 mmHg lower than at baseline.
Multivariate analysis revealed that baseline BP and follow-up duration were positively correlated with BP response.
Conclusion.
Add-on ARA treatment in difficult-to-treat hypertension results in a profound and sustained BP reduction.
American Psychological Association (APA)
Jansen, Pieter M.& Verdonk, Koen& Imholz, Ben P.& Jan Danser, A. H.& van den Meiracker, Anton H.. 2011. Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension : A Retrospective Analysis. International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-466426
Modern Language Association (MLA)
Jansen, Pieter M.…[et al.]. Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension : A Retrospective Analysis. International Journal of Hypertension No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-466426
American Medical Association (AMA)
Jansen, Pieter M.& Verdonk, Koen& Imholz, Ben P.& Jan Danser, A. H.& van den Meiracker, Anton H.. Long-Term Use of Aldosterone-Receptor Antagonists in Uncontrolled Hypertension : A Retrospective Analysis. International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-466426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466426