Determinants of Extraocular Muscle Volume in Patients with Graves' Disease
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-15
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
To examine factors contributing to extraocular muscle (EOM) volume enlargement in patients with Graves’ hyperthyroidism.
Methods.
EOM volumes were measured with orbital magnetic resonance imaging (MRI) in 39 patients with recently diagnosed Graves’ disease, and compared to EOM volumes of 13 normal volunteers.
Thyroid function tests, uptake on thyroid scintigraphy, anti-TSH-receptor antibody positivity and other parameters were then evaluated in patients with EOM enlargement.
Results.
31/39 patients had one or more enlarged EOM, of whom only 2 patients had clinical EOM dysfunction.
Compared to Graves’ disease patients with normal EOM volumes, those with EOM enlargement had significantly higher mean serum TSH (0.020±0.005 versus 0.007±0.002 mIU/L; P value 0.012), free-T4 (52.9±3.3 versus 41.2±1.7 pmol/L; P value 0.003) and technetium uptake on thyroid scintigraphy (13.51±1.7% versus 8.55±1.6%; P value 0.045).
There were no differences between the 2 groups in anti-TSH-receptor antibody positivity, the proportion of males, tobacco smokers, or those with active ophthalmopathy.
Conclusions.
Patients with recently diagnosed Graves’ disease and EOM volume enlargement have higher serum TSH and more severe hyperthyroidism than patients with normal EOM volumes, with no difference in anti-TSH-receptor antibody positivity between the two groups.
American Psychological Association (APA)
El-Kaissi, Samer& Wall, Jack R.. 2012. Determinants of Extraocular Muscle Volume in Patients with Graves' Disease. Journal of Thyroid Research،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-466470
Modern Language Association (MLA)
El-Kaissi, Samer& Wall, Jack R.. Determinants of Extraocular Muscle Volume in Patients with Graves' Disease. Journal of Thyroid Research No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-466470
American Medical Association (AMA)
El-Kaissi, Samer& Wall, Jack R.. Determinants of Extraocular Muscle Volume in Patients with Graves' Disease. Journal of Thyroid Research. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-466470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466470