Fatal Nocardia farcinica Bacteremia Diagnosed by Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry in a Patient with Myelodysplastic Syndrome Treated with Corticosteroids
Joint Authors
Cardaccia, Angela
Furbetta, Leone
Agnelli, Giancarlo
Guercini, Francesco
Moretti, Amedeo
Mencacci, Antonella
Leli, Christian
Bistoni, Francesco
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-16
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Nocardia farcinica is a Gram-positive weakly acid-fast filamentous saprophytic bacterium, an uncommon cause of human infections, acquired usually through the respiratory tract, often life-threatening, and associated with different clinical presentations.
Predisposing conditions for N.
farcinica infections include hematologic malignancies, treatment with corticosteroids, and any other condition of immunosuppression.
Clinical and microbiological diagnoses of N.
farcinica infections are troublesome, and the isolation and identification of the etiologic agent are difficult and time-consuming processes.
We describe a case of fatal disseminated infection in a patient with myelodysplastic syndrome, treated with corticosteroids, in which N.
farcinica has been isolated from blood culture and identified by Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry.
The patient died after 18 days of hospitalization in spite of triple antimicrobial therapy.
Nocardia farcinica infection should be suspected in patients with history of malignancy, under corticosteroid therapy, suffering from subacute pulmonary infection,and who do not respondto conventional antimicrobial therapy.
Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry can be a valuable tool for rapid diagnosis of nocardiosis.
American Psychological Association (APA)
Leli, Christian& Moretti, Amedeo& Guercini, Francesco& Cardaccia, Angela& Furbetta, Leone& Agnelli, Giancarlo…[et al.]. 2013. Fatal Nocardia farcinica Bacteremia Diagnosed by Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry in a Patient with Myelodysplastic Syndrome Treated with Corticosteroids. Case Reports in Medicine،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466482
Modern Language Association (MLA)
Leli, Christian…[et al.]. Fatal Nocardia farcinica Bacteremia Diagnosed by Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry in a Patient with Myelodysplastic Syndrome Treated with Corticosteroids. Case Reports in Medicine No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-466482
American Medical Association (AMA)
Leli, Christian& Moretti, Amedeo& Guercini, Francesco& Cardaccia, Angela& Furbetta, Leone& Agnelli, Giancarlo…[et al.]. Fatal Nocardia farcinica Bacteremia Diagnosed by Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry in a Patient with Myelodysplastic Syndrome Treated with Corticosteroids. Case Reports in Medicine. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-466482
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466482