Nerve Regenerative Effects of GABA-B Ligands in a Model of Neuropathic Pain
Joint Authors
Pajardi, Giorgio
Cavalli, Erica
Colciago, Alessandra
Caffino, Lucia
Castelnovo, Luca Franco
Procacci, Patrizia
Magnaghi, Valerio
Faroni, Alessandro
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Neuropathic pain arises as a direct consequence of a lesion or disease affecting the peripheral somatosensory system.
It may be associated with allodynia and increased pain sensitivity.
Few studies correlated neuropathic pain with nerve morphology and myelin proteins expression.
Our aim was to test if neuropathic pain is related to nerve degeneration, speculating whether the modulation of peripheral GABA-B receptors may promote nerve regeneration and decrease neuropathic pain.
We used the partial sciatic ligation- (PSL-) induced neuropathic model.
The biochemical, morphological, and behavioural outcomes of sciatic nerve were analysed following GABA-B ligands treatments.
Simultaneous 7-days coadministration of baclofen (10 mg/kg) and CGP56433 (3 mg/kg) alters tactile hypersensitivity.
Concomitantly, specific changes of peripheral nerve morphology, nerve structure, and myelin proteins (P0 and PMP22) expression were observed.
Nerve macrophage recruitment decreased and step coordination was improved.
The PSL-induced changes in nociception correlate with altered nerve morphology and myelin protein expression.
Peripheral synergic effects, via GABA-B receptor activation, promote nerve regeneration and likely ameliorate neuropathic pain.
American Psychological Association (APA)
Magnaghi, Valerio& Castelnovo, Luca Franco& Faroni, Alessandro& Cavalli, Erica& Caffino, Lucia& Colciago, Alessandra…[et al.]. 2014. Nerve Regenerative Effects of GABA-B Ligands in a Model of Neuropathic Pain. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-466487
Modern Language Association (MLA)
Magnaghi, Valerio…[et al.]. Nerve Regenerative Effects of GABA-B Ligands in a Model of Neuropathic Pain. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-466487
American Medical Association (AMA)
Magnaghi, Valerio& Castelnovo, Luca Franco& Faroni, Alessandro& Cavalli, Erica& Caffino, Lucia& Colciago, Alessandra…[et al.]. Nerve Regenerative Effects of GABA-B Ligands in a Model of Neuropathic Pain. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-466487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466487