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The Nonglycemic Actions of Dipeptidyl Peptidase-4 Inhibitors
Joint Authors
Yu, Taeyang
Lee, Dae Ho
Kim, Na Hyung
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A cell surface serine protease, dipeptidyl peptidase 4 (DPP-4), cleaves dipeptide from peptides containing proline or alanine in the N-terminal penultimate position.
Two important incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), enhance meal-stimulated insulin secretion from pancreatic β-cells, but are inactivated by DPP-4.
Diabetes and hyperglycemia increase the DPP-4 protein level and enzymatic activity in blood and tissues.
In addition, multiple other functions of DPP-4 suggest that DPP-4 inhibitor, a new class of antidiabetic agents, may have pleiotropic effects.
Studies have shown that DPP-4 itself is involved in the inflammatory signaling pathway, the stimulation of vascular smooth cell proliferation, and the stimulation of oxidative stress in various cells.
DPP-4 inhibitor ameliorates these pathophysiologic processes and has been shown to have cardiovascular protective effects in both in vitro and in vivo experiments.
However, in recent randomized clinical trials, DPP-4 inhibitor therapy in high risk patients with type 2 diabetes did not show cardiovascular protective effects.
Some concerns on the actions of DPP-4 inhibitor include sympathetic activation and neuropeptide Y-mediated vascular responses.
Further studies are required to fully characterize the cardiovascular effects of DPP-4 inhibitor.
American Psychological Association (APA)
Kim, Na Hyung& Yu, Taeyang& Lee, Dae Ho. 2014. The Nonglycemic Actions of Dipeptidyl Peptidase-4 Inhibitors. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-466493
Modern Language Association (MLA)
Kim, Na Hyung…[et al.]. The Nonglycemic Actions of Dipeptidyl Peptidase-4 Inhibitors. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-466493
American Medical Association (AMA)
Kim, Na Hyung& Yu, Taeyang& Lee, Dae Ho. The Nonglycemic Actions of Dipeptidyl Peptidase-4 Inhibitors. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-466493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466493