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Omentin-1 Stimulates Human Osteoblast Proliferation through PI3KAkt Signal Pathway
Joint Authors
Wu, Shan-Shan
Liao, Er-Yuan
Yuan, Ling-Qing
Cui, Rong-rong
Liu, Yuan
Liang, Qiu-Hua
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
It has been presumed that adipokines deriving from adipose tissue may play important roles in bone metabolism.
Omentin-1, a novel adipokine, which is selectively expressed in visceral adipose tissue, has been reported to stimulate proliferation and inhibit differentiation of mouse osteoblast.
However, little information refers to the effect of omentin-1 on human osteoblast (hOB) proliferation.
The current study examined the potential effects of omentin-1 on proliferation in hOB and the signal pathway involved.
Omentin-1 promoted hOB proliferation in a dose-dependent manner as determined by [3H]thymidine incorporation.
Western blot analysis revealed that omentin-1 induced activation of Akt (phosphatidylinositol-3 kinase downstream effector) and such effect was impeded by transfection of hOB with Akt-siRNA.
Furthermore, LY294002 (a selective PI3K inhibitor) and HIMO (a selective Akt inhibitor) abolished the omentin-1-induced hOB proliferation.
These findings indicate that omentin-1 induces hOB proliferation via the PI3K/Akt signaling pathway and suggest that osteoblast is a direct target of omentin-1.
American Psychological Association (APA)
Wu, Shan-Shan& Liang, Qiu-Hua& Liu, Yuan& Cui, Rong-rong& Yuan, Ling-Qing& Liao, Er-Yuan. 2013. Omentin-1 Stimulates Human Osteoblast Proliferation through PI3KAkt Signal Pathway. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-466506
Modern Language Association (MLA)
Wu, Shan-Shan…[et al.]. Omentin-1 Stimulates Human Osteoblast Proliferation through PI3KAkt Signal Pathway. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-466506
American Medical Association (AMA)
Wu, Shan-Shan& Liang, Qiu-Hua& Liu, Yuan& Cui, Rong-rong& Yuan, Ling-Qing& Liao, Er-Yuan. Omentin-1 Stimulates Human Osteoblast Proliferation through PI3KAkt Signal Pathway. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-466506
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466506