Chemical Approaches for Structure and Function of RNA in Postgenomic Era
Joint Authors
Ro-Choi, Tae Suk
Choi, Yong Chun
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-40, 40 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-12
Country of Publication
Egypt
No. of Pages
40
Main Subjects
Abstract EN
In the study of cellular RNA chemistry, a major thrust of research focused upon sequence determinations for decades.
Structures of snRNAs (4.5S RNA I (Alu), U1, U2, U3, U4, U5, and U6) were determined at Baylor College of Medicine, Houston, Tex, in an earlier time of pregenomic era.
They show novel modifications including base methylation, sugar methylation, 5′-cap structures (types 0–III) and sequence heterogeneity.
This work offered an exciting problem of posttranscriptional modification and underwent numerous significant advances through technological revolutions during pregenomic, genomic, and postgenomic eras.
Presently, snRNA research is making progresses involved in enzymology of snRNA modifications, molecular evolution, mechanism of spliceosome assembly, chemical mechanism of intron removal, high-order structure of snRNA in spliceosome, and pathology of splicing.
These works are destined to reach final pathway of work “Function and Structure of Spliceosome” in addition to exciting new exploitation of other noncoding RNAs in all aspects of regulatory functions.
American Psychological Association (APA)
Ro-Choi, Tae Suk& Choi, Yong Chun. 2012. Chemical Approaches for Structure and Function of RNA in Postgenomic Era. Journal of Nucleic Acids،Vol. 2012, no. 2012, pp.1-40.
https://search.emarefa.net/detail/BIM-466512
Modern Language Association (MLA)
Ro-Choi, Tae Suk& Choi, Yong Chun. Chemical Approaches for Structure and Function of RNA in Postgenomic Era. Journal of Nucleic Acids No. 2012 (2012), pp.1-40.
https://search.emarefa.net/detail/BIM-466512
American Medical Association (AMA)
Ro-Choi, Tae Suk& Choi, Yong Chun. Chemical Approaches for Structure and Function of RNA in Postgenomic Era. Journal of Nucleic Acids. 2012. Vol. 2012, no. 2012, pp.1-40.
https://search.emarefa.net/detail/BIM-466512
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466512