Treatment of Chronic Myelomonocytic Leukemia with 5-Azacytidine : Case Reports
Joint Authors
Jonasova, Anna
Holzerova, Milena
Jarosova, Marie
Vondrakova, Jana
Indrak, Karel
Rohon, Peter
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-28
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Epigenetic therapy with hypomethylating agent (5-azacytidine; AZA) is common in the management of specific subtypes of myelodysplastic syndrome (MDS), but there are only few studies in chronic myelomonocytic leukemia (CMML) patients.
In this paper our experience with 3 CMML patients treated with AZA is described.
In one patient transfusion independency was observed after 4 treatment cycles; in one case a partial response was recorded, but a progression to acute myeloid leukemia (AML) after 13 AZA cycles has appeared.
In one patient, AZA in reduced dosage was administered as a bridging treatment before allogeneic stem cell transplantation (ASCT), but in the control bone marrow aspirate (before ASCT) a progression to AML was recorded.
Future studies are mandatory for evaluation of new molecular and clinical features which could predict the efficiency of hypomethylating agents in CMML therapy with respect to overall survival, event-free survival, quality-adjusted life year, and pharmacoeconomy.
American Psychological Association (APA)
Rohon, Peter& Vondrakova, Jana& Jonasova, Anna& Holzerova, Milena& Jarosova, Marie& Indrak, Karel. 2012. Treatment of Chronic Myelomonocytic Leukemia with 5-Azacytidine : Case Reports. Case Reports in Hematology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-466516
Modern Language Association (MLA)
Rohon, Peter…[et al.]. Treatment of Chronic Myelomonocytic Leukemia with 5-Azacytidine : Case Reports. Case Reports in Hematology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-466516
American Medical Association (AMA)
Rohon, Peter& Vondrakova, Jana& Jonasova, Anna& Holzerova, Milena& Jarosova, Marie& Indrak, Karel. Treatment of Chronic Myelomonocytic Leukemia with 5-Azacytidine : Case Reports. Case Reports in Hematology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-466516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466516