Infectious Keratitis : Secreted Bacterial Proteins That Mediate Corneal Damage
Joint Authors
Marquart, Mary E.
O'Callaghan, Richard J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ocular bacterial infections are universally treated with antibiotics, which can eliminate the organism but cannot reverse the damage caused by bacterial products already present.
The three very common causes of bacterial keratitis—Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae—all produce proteins that directly or indirectly cause damage to the cornea that can result in reduced vision despite antibiotic treatment.
Most, but not all, of these proteins are secreted toxins and enzymes that mediate host cell death, degradation of stromal collagen, cleavage of host cell surface molecules, or induction of a damaging inflammatory response.
Studies of these bacterial pathogens have determined the proteins of interest that could be targets for future therapeutic options for decreasing corneal damage.
American Psychological Association (APA)
Marquart, Mary E.& O'Callaghan, Richard J.. 2013. Infectious Keratitis : Secreted Bacterial Proteins That Mediate Corneal Damage. Journal of Ophthalmology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-466517
Modern Language Association (MLA)
Marquart, Mary E.& O'Callaghan, Richard J.. Infectious Keratitis : Secreted Bacterial Proteins That Mediate Corneal Damage. Journal of Ophthalmology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-466517
American Medical Association (AMA)
Marquart, Mary E.& O'Callaghan, Richard J.. Infectious Keratitis : Secreted Bacterial Proteins That Mediate Corneal Damage. Journal of Ophthalmology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-466517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466517