Dried Human Amniotic Membrane Does Not Alleviate Inflammation and Fibrosis in Experimental Strabismus Surgery
Joint Authors
Chun, Bo Young
Shin, Jae Pil
Kim, Hong Kyun
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
The purpose of this study was to evaluate the efficacy of dried human amniotic membrane (AM) in reducing the postoperative inflammatory response and scarring after strabismus surgery.
Methods.
The inflammatory response at the extraocular muscle reattachment site was analyzed after superior rectus (SR) resection in 12 rabbits.
Dried human AM (Ambiodry2) was applied between the resected SR muscle plane and Tenon’s capsule of the left eyes of rabbits.
As a control, the right eyes of rabbits underwent SR resection only.
The surgeon randomly ordered which eye gets operated first during the experiment.
Two weeks later, enucleation was performed.
Six sagittal sections were made for each eye at the insertion of the SR muscle.
The grade of postoperative inflammation and the presence of fibrosis were evaluated in histological examinations.
Results.
There was no statistically significant difference in the intensity of inflammation and fibrous proliferation between the eyes treated with dried human AM after SR resection and those treated with SR resection only.
Conclusions.
The use of dried human AM was not effective in controlling the postoperative inflammation and scarring in rabbit eyes after extraocular muscle surgery.
However, this may be due to the devitalized dry preparation of human AM (Ambiodry2), which may have lost the expected anti-inflammatory and anti-scarring properties, and further studies on humans may be necessary.
American Psychological Association (APA)
Chun, Bo Young& Kim, Hong Kyun& Shin, Jae Pil. 2013. Dried Human Amniotic Membrane Does Not Alleviate Inflammation and Fibrosis in Experimental Strabismus Surgery. Journal of Ophthalmology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-466521
Modern Language Association (MLA)
Chun, Bo Young…[et al.]. Dried Human Amniotic Membrane Does Not Alleviate Inflammation and Fibrosis in Experimental Strabismus Surgery. Journal of Ophthalmology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-466521
American Medical Association (AMA)
Chun, Bo Young& Kim, Hong Kyun& Shin, Jae Pil. Dried Human Amniotic Membrane Does Not Alleviate Inflammation and Fibrosis in Experimental Strabismus Surgery. Journal of Ophthalmology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-466521
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466521