Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients
Joint Authors
Kälsch, Hagen
Gerken, Guido
Erhard, Jochen
Schlattjan, Martin
Kälsch, Julia
Canbay, Ali
Bechmann, Lars P.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hepatocyte apoptosis is a key event in nonalcoholic fatty liver disease (NAFLD), and serum apoptotic markers are emerging as surrogate markers for NAFLD.
We studied the role of caspase-cleaved cytokeratin18 in the diagnosis of fibrosis in a cohort of 127 morbidly obese patients and also performed a review of the literature biomarkers of NAFLD and fibrosis.
Here, we found that cleaved caspase 18 correlated with liver steatosis and liver injury as assessed by serum transaminase levels.
Furthermore, hepatocyte apoptosis as assessed by cleaved CK18 and TUNEL staining correlated with the extent of fibrosis as assessed by Sirius Red staining and serum hyaluronic acid.
These results underscore the important role of hepatocyte apoptosis in the pathogenesis of fibrosis in NAFLD, which led to the utilization of surrogate markers for apoptosis in the noninvasive diagnosis of NAFLD.
We furthermore reviewed current literature of biomarkers of NAFLD and fibrosis.
American Psychological Association (APA)
Kälsch, Julia& Bechmann, Lars P.& Kälsch, Hagen& Schlattjan, Martin& Erhard, Jochen& Gerken, Guido…[et al.]. 2011. Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients. Journal of Nutrition and Metabolism،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-466524
Modern Language Association (MLA)
Kälsch, Julia…[et al.]. Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients. Journal of Nutrition and Metabolism No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-466524
American Medical Association (AMA)
Kälsch, Julia& Bechmann, Lars P.& Kälsch, Hagen& Schlattjan, Martin& Erhard, Jochen& Gerken, Guido…[et al.]. Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients. Journal of Nutrition and Metabolism. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-466524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466524