The Immunologic Basis for Severe Neonatal Herpes Disease and Potential Strategies for Therapeutic Intervention
Joint Authors
Gantt, Soren
Muller, William J.
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-31
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2) infect a large proportion of the world’s population.
Infection is life-long and can cause periodic mucocutaneous symptoms, but it only rarely causes life-threatening disease among immunocompetent children and adults.
However, when HSV infection occurs during the neonatal period, viral replication is poorly controlled and a large proportion of infants die or develop disability even with optimal antiviral therapy.
Increasingly, specific differences are being elucidated between the immune system of newborns and those of older children and adults, which predispose to severe infections and reflect the transition from fetal to postnatal life.
Studies in healthy individuals of different ages, individuals with primary or acquired immunodeficiencies, and animal models have contributed to our understanding of the mechanisms that control HSV infection and how these may be impaired during the neonatal period.
This paper outlines our current understanding of innate and adaptive immunity to HSV infection, immunologic differences in early infancy that may account for the manifestations of neonatal HSV infection, and the potential of interventions to augment neonatal immune protection against HSV disease.
American Psychological Association (APA)
Gantt, Soren& Muller, William J.. 2013. The Immunologic Basis for Severe Neonatal Herpes Disease and Potential Strategies for Therapeutic Intervention. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-466525
Modern Language Association (MLA)
Gantt, Soren& Muller, William J.. The Immunologic Basis for Severe Neonatal Herpes Disease and Potential Strategies for Therapeutic Intervention. Clinical and Developmental Immunology No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-466525
American Medical Association (AMA)
Gantt, Soren& Muller, William J.. The Immunologic Basis for Severe Neonatal Herpes Disease and Potential Strategies for Therapeutic Intervention. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-466525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-466525